Skip to Main content Skip to Navigation
Journal articles

Femtosecond laser impact on calcium phosphate bioceramics assessed by micro-Raman spectroscopy and osteoblastic behaviour

Abstract : The present work is an investigation of the biological response to the presence of grooves 3 μm deep, 15 μm wide and spaced by 100 μm, produced with femtosecond laser on β-tricalcium phosphate (β-TCP). The heat affected zone generated by the laser irradiation was investigated. Micro-Raman spectroscopy showed a transformation from β-TCP phase into α-TCP phase, localised inside the grooves. The X Ray Diffraction analyses, correlated with micro-Raman data, confirmed that the use of femtosecond pulsed laser enables to limit the thermal impact. A selection of optimised process parameters allowed to obtain β-TCP micro-patterned surfaces avoiding any phase transformation. The increase of the wettability with the micro-patterning, compared to smooth surfaces, was highlighted. An improvement of the osteoblastic proliferation was also demonstrated. Finally, the tendency of cell elongation along the grooves direction showed the ability of osteoblastic cells to adapt their morphology to the support topography on which they grow.
Document type :
Journal articles
Complete list of metadatas

https://hal-uphf.archives-ouvertes.fr/hal-03080557
Contributor : Julie Cagniard <>
Submitted on : Thursday, December 17, 2020 - 6:01:37 PM
Last modification on : Thursday, December 17, 2020 - 6:01:39 PM

Links full text

Identifiers

Collections

Citation

Marie Lasgorceix, Liliana Grenho, Maria Helena Fernandes, Cédric Ott, Laurent Boilet, et al.. Femtosecond laser impact on calcium phosphate bioceramics assessed by micro-Raman spectroscopy and osteoblastic behaviour. Journal of the European Ceramic Society, Elsevier, 2018, 38 (16), pp.5545-5553. ⟨10.1016/j.jeurceramsoc.2018.07.048⟩. ⟨hal-03080557⟩

Share

Metrics

Record views

6