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On the influence of marrow on the mechanical behavior of porcine trabecular bone under dynamic loading: a numerical investigation

Abstract : Bone adapts to habitual loading through mechanobiological signaling. Osteocytes are the primary mechanical sensors in bone, upregulating osteogenic factors and downregu-lating osteoinhibitors, and recruiting osteoclasts to resorb bone in response to microdam-age accumulation. However, most of the cell populations of the bone marrow niche, which are intimately involved with bone remodeling as the source of bone osteoblast and osteoclast progenitors, are also mechanosensitive. We hypothesized that the deformation of trabecular bone would impart mechanical stress within the entrapped bone marrow consistent with mechanostimulation of the constituent cells. Detailed fluid-structure interaction models of porcine femoral trabecular bone and bone marrow were created using tetrahedral finite element meshes. The marrow was allowed to flow freely within the bone pores, while the bone was compressed to 2000 or 3000 microstrain at the apparent level. Marrow properties were parametrically varied from a constant 400 mPaÁs to a power-law rule exceeding 85 PaÁs. Deformation generated almost no shear stress or pressure in the marrow for the low viscosity fluid, but exceeded 5 Pa when the higher viscosity models were used. The shear stress was higher when the strain rate increased and in higher volume fraction bone. The results demonstrate that cells within the trabecular bone marrow could be mechanically stimulated by bone deformation, depending on deformation rate, bone porosity, and bone marrow properties. Since the marrow contains many mechanosensitive cells, changes in the stimulatory levels may explain the alterations in bone marrow morphology with aging and disease, which may in turn affect the trabecular bone mechanobiology and adaptation.
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https://hal-uphf.archives-ouvertes.fr/hal-03433040
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Submitted on : Wednesday, November 17, 2021 - 3:33:51 PM
Last modification on : Friday, November 19, 2021 - 3:48:39 AM

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Amina Laouira, Jamila Rahmoun, Hakim Naceur, Pascal Drazetic, Christian Fontaine, et al.. On the influence of marrow on the mechanical behavior of porcine trabecular bone under dynamic loading: a numerical investigation. 40ème Congrès de la Société de Biomécanique (SB 2015), Oct 2015, Paris, France. pp.1974-1975, ⟨10.1080/10255842.2015.1069584⟩. ⟨hal-03433040⟩

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