Cumulative Deleterious Effects of Tetrahydrocannabinoid (THC) and Ethanol on Mitochondrial Respiration and Reactive Oxygen Species Production Are Enhanced in Old Isolated Cardiac Mitochondria.

Anne-Laure Charles (1) , Anne Charloux (1) , Thomas Vogel (1) , Jean-Sébastien Raul (2) , Michel Kindo (1) , Valerie Wolff (1) , Bernard Geny (1)

1 MSP - Mitochondrie, Stress oxydant et Protection musculaire
2 ICube - Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie

Delta 9 tetrahydrocannabinol (THC), the main component of cannabis, has adverse effects on the cardiovascular system, but whether concomitant ethanol (EtOH) and aging modulate its toxicity is unknown. We investigated dose responses of THC and its vehicle, EtOH, on mitochondrial respiration and reactive oxygen production in both young and old rat cardiac mitochondria (12 and 90 weeks). THC dose-dependently impaired mitochondrial respiration in both groups, and such impairment was enhanced in aged rats (-97.5 ± 1.4% vs. -75.6 ± 4.0% at 2 × 10

Mots clés: pharmacology

Domaines: Sciences pharmaceutiques

Anne-Laure Charles, Anne Charloux, Thomas Vogel, Jean-Sébastien Raul, Michel Kindo, et al.. Cumulative Deleterious Effects of Tetrahydrocannabinoid (THC) and Ethanol on Mitochondrial Respiration and Reactive Oxygen Species Production Are Enhanced in Old Isolated Cardiac Mitochondria.. International Journal of Molecular Sciences, 2024, 25 (3), ⟨10.3390/ijms25031835⟩. ⟨hal-04543124⟩