Skip to Main content Skip to Navigation
Theses

Élaboration et analyses structurales de verres bioactifs macroporeux

Abstract : The work concerns the study of bioactive SiO2, CaO, Na2O and P2O5 glasses and presents three parts. In order to connect the structure and the bioactivity, a structural study of these glasses was carried out by 29Si and 31P NMR. The study allowed to show that the progressive phosphorus addition generates an increasingly important polymerization of the silicate network and modifies slightly the phosphate entities chemical nature. The second part relates the macroporous bioactive glass elaboration with controlled porosity by transposing the « Procédé d’élaboration de substituts osseux synthétiques d’architecture poreuse parfaitement maîtrisée » to 43.65SiO2-22.795CaO-30.555Na2O-3P2O5 glass. However, the densification by heat treatment generates a partial crystallization of the glass. The 23Na NMR confirms the glass-ceramic formation. The third part relates to the in vitro bioactivity evaluation as well as preliminary cytocompatibility tests of for the initial glass and the corresponding glass-ceramic. The Infra Red analysis, made on the samples plunged in simulated body fluid (SBF), showed that the glass-ceramic is more bioactive than the glass: apatite was formed after 5h15 immersion for glass-ceramic against 10h15 for glass. The cytocompatibility tests put in evidence no cytotoxicity of the glass-ceramic. This study thus allowed to correlate the glasses structure to their bioactivity. From a very bioactive glass, it was also possible to elaborate a macroporous vitreous ceramic with controlled porosity and with better in vitro bioactivity results.
Complete list of metadatas

https://hal-uphf.archives-ouvertes.fr/tel-03001201
Contributor : Marie Zoia <>
Submitted on : Thursday, November 12, 2020 - 11:49:30 AM
Last modification on : Friday, November 27, 2020 - 4:08:37 PM

File

2007VALE0019_PARDINI_AURELIE.p...
Files produced by the author(s)

Identifiers

  • HAL Id : tel-03001201, version 1

Collections

Citation

Aurélie Pardini. Élaboration et analyses structurales de verres bioactifs macroporeux. Science des matériaux [cond-mat.mtrl-sci]. Université de Valenciennes et du Hainaut-Cambrésis, UVHC, (France), 2007. Français. ⟨NNT : 2007VALE0019⟩. ⟨tel-03001201⟩

Share

Metrics

Record views

6

Files downloads

7