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Frittage, propriétés mécaniques et fonctionnalisation de biocéramiques mono et biphasées

Abstract : This thesis deals with synthesis, densification, mechanical characterization and functionalization of mono- and biphasic calcium phosphate bioceramics. Calcium phosphate powders were synthesized by aqueous precipitation technique by mixing salts of calcium and phosphate. The Ca/P ratio of reactants was adjusted to obtain powders of β-tricalcium phosphate (TCP), hydroxyapatite (HA) and biphasic calcium phosphates containing 20 to 80% of HA (BCP). After calcination, grinding and shaping by slip casting of these powders, materials thus obtained were densified by two techniques: natural sintering and post-sintering by hot isostatic pressing (HIP). The natural sintering of all of these ceramics has led to the achievement of high densification equal or above 98%. The HIP has, in turn, allowed a densification ration close to 100% and made transparent samples, indicating the absence of porosity. Then these sintered materials were mechanically characterized by different techniques allowing determination of Young's modulus, bending strength, hardness and toughness values as a function of HA content. Densification of stoichiometric calcium phosphates to nearly 100% leads to the intrinsic properties of these biomaterials. Biological assays, functionalization by phage and an antibiotic have finally been realized on these materials.
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Emmanuelle Rguiti-Constantin. Frittage, propriétés mécaniques et fonctionnalisation de biocéramiques mono et biphasées. Génie mécanique [physics.class-ph]. Université de Valenciennes et du Hainaut-Cambrésis, 2011. Français. ⟨NNT : 2011VALE0032⟩. ⟨tel-03416182⟩



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